Background and aim: Hepatorenal toxicity is a very common ailment with\nresultant deleterious burden on the overall body systems and high mortality\nrate. Although myriads of drug agents are in circulation, its medical management\nis still inadequate as no effective treatment which inhibits disease\nprogression and complications, has been synthesized yet. Therefore, this\nstudy focused on the potentials of Kigelia africana ethanolic leaf extract\n(KAELE) in preventing hepatorenal toxicity using CCl4 model of toxicity in\nrats. Method: KAELE was subjected to phytochemical screening. Following\ntwo-week acclimatization, thirty-six (N = 36) adult male Wistar rats were\ngrouped into six consisting of six animals each (n = 6). Group I was given\ndistilled water as control while groups II to VI received silymarin (100\nmg/kg), CCl4 (1 ml/kg), KAELE (100 mg/kg, 200 mg/kg and 400 mg/kg) respectively.\nAll groups pre-treated with silymarin and Kigelia africana ethanol\nleaf extract lasted for a period of fourteen (14) days using a gastric tube. CCl4\nwas administered intraperitoneally to groups II, III, IV, V and VI 48 hours\nafter the last pretreatment on day 14. Post treatment, animals were sacrificed\nand the blood obtained and sera used for biochemical analysis while the tissues\nfor histological evaluations. Results : The phytochemical tests revealed\nthe presence of flavonoids, tannins, steroids, terpenoids, saponins, glycosides,........................
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